High Resolution, Scalable Membrane Chromatography
From the inventors of the Chromassette® Platform, a modular chromatography device for bead-based media, the ChromaWeb® cassette solves the challenge of achieving very uniform distribution across a large frontal area with a shallow bed.
The ChromaWeb® device is a stackable adsorptive cassette suitable for planar media, including membranes, nonwoven webs and monoliths. It is novel and highly differentiated:
It is linearly scalable.
It has high resolution in spite of a shallow bed.
In fact, it is the only chromatographic platform for shallow beds that is both high-resolution and scalable. Because of this, the ChromaWeb® Cassette is the only practical configuration for scale-up of planar adsorptive media.
Critical for Unlocking Cutting Edge Therapeutics
A new class of therapeutics is set to boom in the coming decade based on gene therapy and viral vectors delivered in and ex vivo. These vectors are too large for chromatographic beads to be effective, having a molecular dimension 20~350 nm. The downstream processing of these agents is in its early stages with few (or no) devices suitable for their purification. Large pore adsorptive media, with pores of 1~6 µm will be necessary to serve this growing application class. The ChromaWeb® platform is the only platform compatible with this class of media that is also high-resolution and scalable.
A Modular Chromatography Platform
Right-sizing of adsorptive media
Easy to assemble & set up
Protected by issued and pending patents
ChromaWeb® Cassette – Very Low Dispersion
The superior flow distribution within a ChromaWeb® cassette leads to a high plate count and an asymmetry near 1. As cassettes are stacked, the bed volume grows linearly while maintaining high performance.
|Serial #||Test Date||N||N||Assymetry||V0|
|88080||7 Nov 2021||160||22,222||1.32||12.0|
The ChromaWeb® is Available for Licensing
Contact us if you are interested in learning how the ChromaWeb® cassette delivers higher productivity, lower buffer consumption and seamless scale-up. Product samples with strong anion media are available for evaluation.