The Chromassette® platform is available for evaluation!

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Chromassette® devices are chromatography columns in the form of a cassette. It is the first practical modular chromatography platform, offering truly linear scale-up, which until now has been an elusive property desired by anyone practicing chromatography.

Chromassette® devices are further characterized by a bed-supporting structure that prevents the compression of chromatographic beads even at high velocities exceeding 1000 cm/hr.

The Chromassette® Technology is exclusively licensed to JSR Corporation for Biopharmaceutical Processing. If you are want to learn more about the Chromassette technology for biopharm processes contact JSR Corporation or go to the Chromassette webpage in JSR Life Sciences.

Problems with Conventional Chromatographic Devices

  • Beads must be packed into a column. The quality of this packing determines the performance of the adsorbing bed. This adds another source of variability to the chromatographic process and must be validated before use.

  • Beds packed with beads are prone to voiding, a phenomenon whereby the beads settle into a denser structure resulting in the creation of voids and in non-homogeneities in the packing density of the bed, all of which result in a deterioration of performance. This is especially true in columns packed with soft beads.

  • Existing chromatographic devices are not linearly scalable, their design and geometry requiring significant alterations as the device size increases, thereby introducing uncertainties and unwanted risks as processes evolve from drug discovery, to clinical trials, to small-scale and then large-scale manufacturing.

A Novel Adsorptive Device

A cross-section of a Chromassette device showing the top and
						 bottom plates, the peripheral seal wall, and inner scaffold for
						 structural support. Two rows of through-holes perpendicular to the
						 top and bottom plates are positioned between the scaffold and
						 peripheral seal. The row near the peripheral seal is labeled
						 'Distributor Holes,' and the row near the scaffold is labeled 'Frit
  • The separation capability of conventional chromatography with the features and benefits of a cassette format

  • Distinguished by a supporting bed scaffold

  • Capable of supporting any bead

A Deeper Look at the Advantages of Chromassette®