Chromassette®

Chromassette devices are chromatography columns in the form of a cassette. It is the first practical modular chromatography platform, offering truly linear scale-up, which until now has been an elusive property desired by anyone practicing chromatography.

Chromassette devices are further characterized by a bed-supporting structure that prevents the compression of chromatographic beads even at high velocities exceeding 1000 cm/hr.

Problems with Conventional Chromatographic Devices

• Beads must be packed into a column. The quality of this packing determines the performance of the adsorbing bed. This adds another source of variability to the chromatographic process and must be validated before use.

• Beds packed with beads are prone to voiding, a phenomenon whereby the beads settle into a denser structure resulting in the creation of voids and in non-homogeneities in the packing density of the bed, all of which result in a deterioration of performance. This is especially true in columns packed with soft beads.

• Existing chromatographic devices are not linearly scalable: their design and geometry require significant alterations as the device size increases, thereby introducing uncertainties and unwanted risks as processes evolve from drug discovery, to clinical trials, to small-scale and then large-scale manufacturing.

A Novel Adsorptive Device

• The separation capability of conventional chromatography with the features and benefits of a cassette format

• Distinguished by a supporting bed scaffold

• Capable of supporting any bead

A Deeper Look at the Advantages of Chromassette®