IP Portfolio
SPF Technologies holds several U.S. patents and has several pending domestic and foreign patent applications. The SPF business model is to secure patent rights on our inventions, develop the inventions, and license the technology to top suppliers. We also provide assistance with manufacturing and marketing. This way we are able to leverage the sales and marketing capability of existing suppliers and thereby accelerate the adoption of our new technologies.
SP-TFF™ Process Patents (Licensed to Pall Corporation)
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U.S. Patent 10,421,043 Method and Apparatus for the Filtration of Biological Solutions
(PDF)
[online text version]
A system, method, and device are disclosed for bioprocessing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates and the process can also be used to provide constant output diafiltration.
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U.S. Patent 9,662,614 Method and apparatus for the filtration of biological solutions
(PDF)
[online text version]
See the continuation patent: 10,421,043.
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U.S. Patent 8,728,315 Method and apparatus for the filtration of biological solutions
(PDF)
[online text version]
Continued by continuation patent 9,662,614 above, and its continuation patent, 10,421,043.
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U.S. Patent 8,157,999 Method and apparatus for the filtration of biological solutions
(PDF)
[online text version]
See patent 10,421,043 for description.
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U.S. Patent 7,967,987 Method and apparatus for the filtration of biological solutions
(PDF)
[online text version]
See patent 10,421,043 for description.
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U.S. Patent 7,682,511 Method and apparatus for the filtration of biological solutions
(PDF)
[online text version]
See patent 10,421,043 for description.
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U.S. Patent 7,384,549 Method and apparatus for the filtration of biological solutions
(PDF)
[online text version]
See patent 10,421,043 for description.
SP-TFF™ Sample Prep Patents
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U.S. Patent 8,747,669 Method and apparatus for the filtration of
biological samples
(PDF)
[online text version]
A separation module and method are disclosed for processing a liquid sample and providing high conversion by operating a single-pass tangential-flow process without a recirculation loop. In one embodiment, the separation module includes three reservoirs and has at least one long, thin channel with a large ratio of channel membrane area to: channel void volume; volume of a sample feed reservoir; and volume of the feed sample. In another embodiment, the separation module includes an external feed reservoir, an external retentate reservoir fluidly and a first vacuum source adapted to apply a first vacuum to the separation element disposed within the housing. The single-pass TFF separation element and single-pass process provides high conversion while operating with relatively low pressure sources. Certain embodiments disclosed herein can be used for the separation of blood.
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U.S. Patent 8,231,788 Method and apparatus for the filtration of
biological samples
(PDF)
[online text version]
A separation module and method are disclosed for processing a liquid sample and providing high conversion by operating a single-pass tangential-flow process without a recirculation loop. In one embodiment, the separation module includes three reservoirs and has at least one long, thin channel with a large ratio of channel membrane area to: channel void volume; volume of a sample feed reservoir; and volume of the feed sample. In another embodiment, the separation module includes two reservoirs and a hydrophobic vent. The single-pass process provides high conversion while operating with relatively low pressure sources.
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U.S. Patent 8,231,787 Tangential flow filtration system
(PDF)
[online text version]
A system, method and device are disclosed for bio-processing a feed stream providing a constant output by operating a continuous single-pass tangential-flow process. Embodiments are operated without large circulation pumps. Other embodiments use components which can be disposed after a single use. The system, method and device can also be used to provide constant output diafiltration.
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U.S. Patent 7,510,654 Method and apparatus for the filtration of
biological samples
(PDF)
[online text version]
See the continuation patent: 8,231,788.
UTF™ Patents
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U.S. Patent 10,518,222 Cycling ultra-thin channel filtration
(PDF)
[online text version]
A cycling ultra-thin channel filtration (cUTF) method, system and module are disclosed for concentration and purification of biomolecules. In one embodiment, a cUTF system includes a cUTF module and a cycle controller to load a feed aliquot of a feed stream into the cUTF module inducing permeation of the feed stream to build a boundary layer by pressurizing the feed stream, to stop permeation and to recover a retentate aliquot in a repeating cycle.
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U.S. Patent 9,511,326 Cycling ultra-thin channel filtration
(PDF)
[online text version]
See the continuation patent: 10,518,222.
Chromassette® Patents
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U.S. Patent 10,507,409 Hyper-productive chromatography system
and process
(PDF)
[online text version]
A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.
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U.S. Patent 10,391,423 Stackable planar adsorptive devices
(PDF)
[online text version]
A lattice and distribution network for a stackable chromatography cassette comprising:
a peripheral seal;
at least one screne forming the lattice surrounded by the peripheral seal, each at least one screen comprising a plurality of struts in a latticed arrangement;
a first internal distribution network fluidly coupled to the lattice and surrounded by the peripheral seal;
wherein a direction of fluid flow is established from the first internal distribution network through the lattice to the second internal distribution network; and
wherein preferential streamlines are minimized.
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U.S. Patent 9,599,594 Stackable planar adsorptive devices
(PDF)
[online text version]
Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs compressive stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing. In one embodiment the adsorptive bed in packed into a chromatography column, and in another embodiment the adsorptive bed is sealed in a monolithic block. In another embodiment, the adsorptive bed device includes an adsorptive block, first and second planar distributors, and peripheral seal. The adsorptive media includes multiple layers of planarly cohesive media and when operated in a shallow bed configurationm possesses significant tensile strength along its planar dimensions enabling it to support the hydraulic pressures that will be generated by the fluids being process through the adsorptive devices.
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U.S. Patent 9,210,037 Stackable planar adsorptive devices
(PDF)
[online text version]
Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs compressive stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing. In one embodiment the adsorptive bed in packed into a chromatography column, and in another embodiment the adsorptive bed is sealed in a monolithic block.
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U.S. Patent 8,506,802 Stackable planar adsorptive devices
(PDF)
[online text version]
Stackable planar adsorption devices include a plurality of layers of adsorptive media provided in a web format. The layers are stacked in contiguous fashion, sealed and include fluid passageways to provide a range of scalable chromatography devices suitable for large scale manufacturing applications.